Malegra 120mg, which contains sildenafil, is primarily used to treat erectile dysfunction. It can interact with several other medications, leading to either increased side effects or reduced effectiveness. For example, when taken with nitrates (often used for chest pain), it can cause a dangerous drop in blood pressure. It can also interact with alpha-blockers, used to treat high blood pressure or prostate conditions, increasing the risk of hypotension. Other interactions may occur with certain antifungal medications (like ketoconazole), HIV protease inhibitors, and certain antibiotics. Always consult a healthcare provider before combining Malegra 120 with other medications to avoid serious side effects.