The timing for applying the best tattoo numbing creams can vary depending on the type and strength of the cream. Some creams may take longer to take effect, so it's important to follow the instructions on the cream carefully. Generally, it's recommended to apply the cream about 30-60 minutes before the tattooing process begins. However, some artists may prefer to apply the cream themselves, so it's important to check with your artist beforehand to make sure you're following their instructions.