Zebrafish cancer models are rapidly gaining popularity and yielding clinically translatable insights. The zebrafish model system has several advantages over other animal models. Their high fecundity and low rearing costs allow for extensive genetic screening. Zebrafish are transparent and develop externally, allowing in vivo imaging and analysis of normal organogenesis mechanisms. In addition, small molecule drugs can be added directly to zebrafish water. If a larval stage phenotype is discovered, high-throughput chemical screening of the whole organism can be performed to identify relevant signaling pathways and evaluate potential mechanisms of molecular intervention.